A Shh coreceptor Cdo is required for efficient cardiomyogenesis of pluripotent stem cells
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- 作者：Myong-Ho Jeonga ; d ; Young-Eun Leema ; d ; Hyun-Ji Kimb ; d ; Kyungjin Kangc ; d ; Hana Chob ; d ; hanacho@skku.edu" class="auth_mail" title="E-mail the corresponding author ; Jong-Sun Kanga ; d ; kangj01@skku.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Stem cells ; Cdo ; Sonic hedgehog ; Cardiomyogenesis ; Connexin 43 ; Cardiomyocytes
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：57-66
- 全文大小：2151 K
文摘
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Cdo regulates cardiomyogenesis via Shh signaling activation.
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Cdo deficiency down-regulates key cardiac regulators in P19 EC and Cdo−/− mES cell.
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Cdo deficiency causes reduced formation of contracting mature cardiomyocytes.
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Shh agonist restored synchronous contracting properties in Cdo-deficient EBs.
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Shh agonist restored the junctional expression of Cx43 in Cdo-deficient EBs.