Cdo regulates cardiomyogenesis via Shh signaling activation.
Cdo deficiency down-regulates key cardiac regulators in P19 EC and Cdo−/− mES cell.
Cdo deficiency causes reduced formation of contracting mature cardiomyocytes.
Shh agonist restored synchronous contracting properties in Cdo-deficient EBs.
Shh agonist restored the junctional expression of Cx43 in Cdo-deficient EBs.