Alteration of the cytokine signature by various TLR ligands in different T cell populations in MOG37-50 and MOG35-55-induced EAE in C57BL/6 mice
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- 作者：Corinna Steckner ; Corinna.Steckner@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Andreas Weber ; Anne K. Mausberg ; Maximilian Heininger ; Felicitas Opdenhö ; vel ; Bernd C. Kieseier ; Hans P. Hartung ; Harald H. Hofstetter
- 关键词：EAE ; MOG ; IL-17 ; T cell ; TLR
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：170
- 期：Complete
- 页码：22-30
- 全文大小：1082 K
文摘
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A similar cytokine phenotype - with CD4 + T cells as main producer - in the outgoing immune process of MOG37–50- and MOG35–55-induced EAE
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Migratory activity supports an involvement of IL-17 and IFN-γ in the disease.
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PAMPs – dependent on distinct factors - costimulated IL-17- and IFN-γ-producing cells.