β-(1 → 3,1 → 6)-d-glucans produced by Diaporthe sp. endophytes: Purification, chemical characterization and antiproliferative activity against MCF-7 and HepG2-C3A cells

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• 作者：Ravely Casarotti Orlandelli^a ; Maria de Lourdes Corradi da Silva^b ; ^{corradi@fct.unesp.br} ; Ana Flora Dalberto Vasconcelos^b ; Igor Vivian Almeida^a ; Veronica Elisa Pimenta Vicentini^a ; Alicia Prieto^c ; Maria Dolores Diaz Hernandez^c ; Joã ; o Lú ; cio Azevedo^d ; Joã ; o Alencar Pamphile^a
• 关键词：Endophytic fungi ; Exopolysaccharide ; MTT assay ; Spectroscopic analysis
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：part_PA
• 页码：431-437
• 全文大小：971 K
• 卷排序：94

文摘

β-glucans (EPS-P) were purified from the fermentation broth of two Diaporthe endophytes. β-glucans consisted of a main chain of glucopyranosyl (1 → 3) linkages substituted at O-6 by glucosyl residues. EPS-PD2 inhibited up to ∼75% of the proliferation of MCF-7 cells. Both glucans inhibited up to ∼84% of the proliferation of HepG2-C3A cells.