Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence
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- 作者：Mariangela Succoioa ; b ; 1 ; Marika Comegnaa ; b ; 1 ; Chiara D'Ambrosioc ; Andrea Scalonic ; Filiberto Ciminoa ; b ; cimino@dbbm.unina.it" class="auth_mail" title="E-mail the corresponding author ; Raffaella Faraonioa ; b ; faraonio@dbbm.unina.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chip-qPCR ; chromatin immunoprecipitation quantitative polymerase chain reaction ; COL1A1 ; collagen alpha-1(I) chain ; DDR ; DNA damage response ; DEM ; diethylmaleate ; EJC ; exon junction complex ; ETP ; etoposide ; H3K4me3 ; trimethylation of histone H3 at Lys4 ; H3K27me3 ; trimethylation of histone H3 at Lys27 ; LEPRE1 ; prolyl 3-hydroxylase 1 ; LIMA1 ; LIM domain and actin-binding protein 1 ; MAGOH ; mago-nashi homolog ; proliferation-associated ; MMP3 ; matrix metallopeptidase 3 ; NMD ; nonsense-mediated mRNA deca
- 刊名：Journal of Proteomics
- 出版年：2015
- 出版时间：14 October 2015
- 年：2015
- 卷：128
- 期：Complete
- 页码：18-29
- 全文大小：1340 K
文摘
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Comparative proteomic analysis of replicative and stress-induced senescent cells.
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Identification of novel genes that, when down-regulated, induce a senescent phenotype.
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Distinctive methylation marks of LEPRE1, LIMA1, MAGOHA and MAGOHB promoters.
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In vitro and in vivo senescence correlate with down-regulation of these genes.