Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression
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- 作者：Maurizio Bergaminoa ; 1 ; mbergamino@laureateinstitute.org" class="auth_mail" title="E-mail the corresponding author ; Ofer Pasternakb ; 2 ; ofer@bwh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Madison Farmera ; 1 ; mfarmer@laureateinstitute.org" class="auth_mail" title="E-mail the corresponding author ; Martha E. Shentonb ; c ; 2 ; shenton@bwh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; J. Paul Hamiltona ; d ; 3 ; paul.hamilton@cal.berkeley.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diffusion tensor imaging ; Free-water corrected DTI ; Major depressive disorder ; Tract-based spatial statistics ; Fractional anisotropy ; Axial diffusivity
- 刊名：NeuroImage: Clinical
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：10
- 期：Complete
- 页码：336-342
- 全文大小：698 K
文摘
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DTI suffers from partial volume effects that limit the estimation of white-matter integrity in major depressive disorder.
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Applying a free-water correction to DTI data improves the sensitivity of DTI metrics to identify effects in depression.
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Reductions in free-water DTI metrics in depression were associated with increased stress.