Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system
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- 作者：Sandro Dá ; Mesquitaa ; b ; Ana Catarina Ferreiraa ; b ; Joã ; o Carlos Sousaa ; b ; Margarida Correia-Nevesa ; b ; Nuno Sousaa ; b ; Fernanda Marquesa ; b ; fmarques@ecsaude.uminho.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; Aging ; Amyloid beta ; Cognition ; Blood-brain barrier ; Choroid plexus ; Cerebrospinal fluid ; Glial cells ; Neurons ; Cytokines ; Neuroinflammation ; Immune system
- 刊名：Neuroscience & Biobehavioral Reviews
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：547-562
- 全文大小：1380 K
文摘
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Increased brain amyloid burden and neuroinflammation are central features of AD.
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The brain barriers play a role in the inflammatory response in aging and in AD.
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All brain parenchymal cell types take part in the neuroinflammatory response in AD.
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The peripheral immune system modulates both brain pathology and cognition in AD.