Subconvulsant doses of pentylenetetrazol uncover the epileptic phenotype of cultured synapsin-deficient Helix serotonergic neurons in the absence of excitatory and inhibitory inputs
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- 作者：Oscar Brenesa ; b ; oscar.brenes_g@ucr.ac.cr" class="auth_mail" title="E-mail the corresponding author ; oscar.brenesgarcia@edu.unito.it" class="auth_mail" title="E-mail the corresponding author ; Valentina Carabellic ; d ; Sara Gossoc ; d ; Adarli Romeroe ; Emilio Carbonec ; d ; Pier Giorgio Montaroloa ; f ; Mirella Ghirardia ; f
- 关键词：AP ; action potential ; ISI ; interspike interval ; PDS ; paroxysmal depolarization shift ; Syn ; synapsin ; TKO ; triple knock-out ; PTZ ; pentylenetetrazol ; MEA ; microelectrode array ; helSynKD ; Helix synapsin knock-down ; CC ; cross-correlogram
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：241-251
- 全文大小：2156 K
文摘
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Synapsin-silenced cells lacking synaptic inputs exhibit greater PTZ susceptibility.
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PTZ-induced epileptic-like behaviors were increased in synapsin-silenced cells.
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Recurrent epileptic-like activity impairs control neuron synaptogenesis.
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Recurrent epileptic-like activity is associated with spontaneous spiking activity.