The biological activity of cationic liposomes in drug delivery and toxicity test in animal models
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- 作者：Panpan Qia ; 1 ; 1130342553@qq.com" class="auth_mail" title="E-mail the corresponding author ; Mei Caoa ; b ; 1 ; cm1023@163.com" class="auth_mail" title="E-mail the corresponding author ; Liju Songa ; 1255879146@qq.com" class="auth_mail" title="E-mail the corresponding author ; Chong Chena ; 1737947882@qq.com" class="auth_mail" title="E-mail the corresponding author ; Mingdong Liua ; 136943961@qq.com" class="auth_mail" title="E-mail the corresponding author ; Ningzhe Lia ; 710192880@qq.com" class="auth_mail" title="E-mail the corresponding author ; Daoyan Wua ; 1104322181@qq.com" class="auth_mail" title="E-mail the corresponding author ; Jingshan Penga ; 421998791@qq.com" class="auth_mail" title="E-mail the corresponding author ; Guoku Hub ; c ; huguoku@163.com" class="auth_mail" title="E-mail the corresponding author ; Jian Zhaoa ; zj804@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DOTAP ; 1 ; 2-dioleoyl-3-trimethylammonium ; DOPE ; 1 ; 2-dioleoyl-snglycero-3-phosphoethanolamine ; PEG-PE ; polyethylene glycol-polyethylene ; EPR ; enhanced permeability and retention ; RNAi ; RNA interference ; Aurora A ; Aurora kinase A ; Aurora B ; Aurora kinase B ; Aurora C ; Aurora kinase C ; HE ; Hematoxylin Eosin ; MPS ; mononuclear phagocyte system
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：47
- 期：Complete
- 页码：159-164
- 全文大小：3558 K
文摘
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The molar ratio of DOTAP and DOPE with PEG-PE is 1:1:0.01 and they were dissolved in chloroform methanol solution (3:1, volume ratio). Cationic liposomes were prepared using an extrusion method.
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The Cationic liposomes have high transfection efficiency whether in vitro or in vivo.
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The Cationic liposomes have no significant adverse consequences in liposomes treated mice.