Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats
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- 作者：Pan Luoa ; 1 ; Cheng Chena ; 1 ; Yun Lua ; TianLi Fua ; Qing Lua ; Xulin Xua ; Changjun Lia ; Zhi Heb ; hezhi2003@126.com.cn" class="auth_mail" title="E-mail the corresponding author ; Lianjun Guoa ; ljguo@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：GABAB receptors ; Chronic cerebral hypoperfusion ; Spatial working memory ; HCN subunits ; PFC
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：308
- 期：Complete
- 页码：6-13
- 全文大小：2577 K
文摘
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Baclofen could ameliorate spatial working memory impairment induced by CCH.
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Baclofen could reverse the CCH-induced decrease of HCN2 expression in the PFC.
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That HCN2 may target PV-interneurons is implicated in working memory processes.