Activation of GABAB2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels
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- 作者：Yun Lua ; 1 ; Chang-jun Lib ; 1 ; Cheng Chena ; Pan Luoa ; Mei Zhoua ; Cai Lia ; Xu-lin Xua ; c ; Qing Lua ; c ; Zhi Hed ; hezhi2003@126.com.cn" class="auth_mail" title="E-mail the corresponding author ; Lian-jun Guoa ; c ; ljguo@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anxiety-like behaviour ; Chronic cerebral hypoperfusion ; GABAB2 subunit ; BDNF/TrkB/NCAM ; Kir3 channels
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PA
- 页码：308-321
- 全文大小：3217 K
文摘
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Chronic cerebral hypoperfusion could induce anxiety-like behaviours in rats.
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Activation of GABAB2 subunits could alleviate the anxiety-like behaviours.
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Activation of GABAB2 subunits could improve BDNF signalling in 2VO rats.
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Activation of GABAB2 subunits could reverse Kir3 surface expression in 2VO rats.