Renoprotective approaches and strategies in acute kidney injury

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• 作者：Yuan Yang^a ; Meifang Song^a ; Yu Liu^a ; Hong Liu^a ; Lin Sun^a ; Youming Peng^a ; Fuyou Liu^a ; ^{lfy2061@163.com" class="auth_mail" title="E-mail the corresponding author} ; Manjeri A. Venkatachalam^b ; Zheng Dong^a ; ^c ; ^{zdong@augusta.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ACTH ; Adrenocorticotropic hormone ; AIF ; Apoptosis inducing factor ; AKI ; Acute kidney injury ; BMSC ; Bone marrow derived stem cells ; CIN ; Contrast-induced nephropathy ; COMP-Ang1 ; Cartilage oligomeric matrix protein-angiopoietin-1 ; CysLT1R ; Cysteinyl leukotriene-1 receptor ; DMARD ; Disease-modifying antirheumatic drugs ; eNOS ; Endothelial nitric oxide synthase ; eEPCs ; Endothelial progenitor cells ; HDAC ; Histone deacetylase ; HSPC ; Hematopoietic stem and progenitor cells ; IRI ; Ischemia&ndash ; reperfusio
• 刊名：Pharmacology and Therapeutics
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：163
• 期：Complete
• 页码：58-73
• 全文大小：1116 K

文摘

Acute kidney injury (AKI) is a major renal disease associated with high mortality rate and increasing prevalence. Decades of research have suggested numerous chemical and biological agents with beneficial effects in AKI. In addition, cell therapy and molecular targeting have been explored for reducing kidney tissue damage and promoting kidney repair or recovery from AKI. Mechanistically, these approaches may mitigate oxidative stress, inflammation, cell death, and mitochondrial and other organellar damage, or activate cytoprotective mechanisms such as autophagy and pro-survival factors. However, none of these findings has been successfully translated into clinical treatment of AKI. In this review, we analyze these findings and propose experimental strategies for the identification of renoprotective agents or methods with clinical potential. Moreover, we propose the consideration of combination therapy by targeting multiple targets in AKI.