Formulation and characterization of a plasma sterilized, pharmaceutical grade chitosan powder
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- 作者：Andrew R. Croftona ; c ; acrofton@llu.edu" class="auth_mail" title="E-mail the corresponding author ; Samuel M. Hudsond ; shudson@ncsu.edu" class="auth_mail" title="E-mail the corresponding author ; Kristy Howardc ; khoward@llu.edu" class="auth_mail" title="E-mail the corresponding author ; Tyler Penderc ; tpender@llu.edu" class="auth_mail" title="E-mail the corresponding author ; Abdelrahman Abdelgawadd ; aabdelg@ncsu.edu" class="auth_mail" title="E-mail the corresponding author ; Daniel Wolskid ; dwolski@ncsu.edu" class="auth_mail" title="E-mail the corresponding author ; Wolff M. Kirschb ; c ; wkirsch@llu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CS ; chitosan ; NtNP ; non-thermal nitrogen plasma ; ApP ; atmospheric pressure plasma ; LpP ; low-pressure plasma ; DD ; degree of deacetylation
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：420-426
- 全文大小：1684 K
文摘
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Chitosan was micronized by cryo-ball and cryo-jet milling.
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Mean particle size after cryo-jet mill (16.05 μm) was smaller than cryo-ball mill.
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Cryomilling reduced molecular weight by 26% and degree of deacetylation by 9.6%.
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Nitrogen plasma treatment produced sterile chitosan with endotoxins at <2.5 EU/g.
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Nitrogen plasma treatment also reduced molecular weight of chitosan.