A novel infection- and inflammation-associated molecular signature in peripheral blood of myasthenia gravis patients
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- 作者：Claudia Barzagoa ; b ; claudia.barzago@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Josephine Luma ; josephine_lum@immunol.a-star.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Paola Cavalcanteb ; paola.cavalcante@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Kandhadayar Gopalan Srinivasana ; srinivasan_kg@immunol.a-star.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Elisa Faggianib ; elisa.faggiani@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Giorgia Camerab ; giorgia.camera@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Silvia Bonannob ; silvia.bonanno@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Francesca Andreettab ; francesca.andreetta@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Carlo Antozzib ; carlo.antozzi@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Fulvio Baggib ; fulvio.baggi@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Raffaele Adolfo Calogeroc ; raffaele.calogero@unito.it" class="auth_mail" title="E-mail the corresponding author ; Pia Bernasconib ; pia.bernasconi@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Renato Mantegazzab ; renato.mantegazza@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Lucia Moria ; lucia.mori@unibas.ch" class="auth_mail" title="E-mail the corresponding author ; Francesca Zolezzia ; francesca.zolezzi@galderma.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AChR ; acetylcholine receptor ; AChR-EOMG ; acetylcholine receptor-early onset AChR-MG ; AZA ; azathioprine ; IPA ; Ingenuity Pathway analysis ; lincRNAs ; long non-coding intergenic RNAs ; lncRNAs ; long non-coding RNAs ; MG ; myasthenia gravis ; miRNAs ; microRNAs ; pre-miRNAs ; miRNA precursors ; NMJ ; neuromuscular junction ; PBMCs ; peripheral blood mononuclear cells ; RNA-seq ; RNA-sequencing
- 刊名：Immunobiology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：221
- 期：11
- 页码：1227-1236
- 全文大小：1721 K
文摘
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AChR-EOMG patients showed alterations in 178 coding transcripts and 229 lncRNAs.
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Altered transcripts are characteristic of an infection/inflammation signature.
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These transcript alterations were newly described in association with MG.