Wharton's jelly mesenchymal stromal cells have contrasting effects on proliferation and phenotype of cancer stem cells from different subtypes of lung cancer
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- 作者：Francesca Vulcanoa ; 1 ; francesca.vulcano@iss.it" class="auth_mail" title="E-mail the corresponding author ; Luisa Milazzoa ; 1 ; luisa.milazzo@iss.it" class="auth_mail" title="E-mail the corresponding author ; Carmela Ciccarellib ; carmela.ciccarelli@univaq.it" class="auth_mail" title="E-mail the corresponding author ; Adriana Eramoa ; adriana.eramo@iss.it" class="auth_mail" title="E-mail the corresponding author ; Giovanni Settec ; giovanni.sette@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Annunziata Maurod ; amauro@unite.it" class="auth_mail" title="E-mail the corresponding author ; Giampiero Maciocea ; giampiero.macioce@iss.it" class="auth_mail" title="E-mail the corresponding author ; Andrea Martinellie ; andrea.martinelli@iss.it" class="auth_mail" title="E-mail the corresponding author ; Renato La Torref ; renato.latorre@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Patrizia Casalboreg ; patrizia.casalbore@cnr.it" class="auth_mail" title="E-mail the corresponding author ; Hamisa Jane Hassana ; 2 ; jane.hassan@iss.it" class="auth_mail" title="E-mail the corresponding author ; Adele Giampaoloa ; 2 ; adele.giampaolo@iss.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AC ; adenocarcinoma ; ALDH ; aldehyde dehydrogenase ; CSC ; cancer stem cells ; DEAB ; diethylaminobenzaldehyde ; FITC ; fluorescein isothiocyanate ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GLDC ; glycine decarboxylase ; HE ; hematoxylin-eosin ; LCSC ; lung cancer stem cells ; MSC ; mesenchymal stromal cells ; NHDF ; normal human dermal fibroblast ; NHDF-CM ; normal human dermal fibroblast &ndash ; conditioned medium ; PE ; phycoerythrin ; PI ; proliferation index ; SCC ; squamous cell carcinoma ; WJ-CM ; Wharton's
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：345
- 期：2
- 页码：190-198
- 全文大小：3759 K
文摘
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CM from WJMSC induces apoptosis of SCC-LCSC and reduction of ALDH+ and CD133+ cells.
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Specificity of SCC-LCSC inhibition by WJ-CM is proved by the use of a CM from NHDF.
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WJ-CM enhance AC-LCSC proliferation and increase CD133+ and ALDH+ cell fractions.
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Coinjection of WJMSC with AC-LCSC increase tumor growth with SCC-LCSC has no effect.