Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis
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- 作者：Alicja Kalinowska-Łyszczarz ; MDa ; akalinowskalyszczarz@ump.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Sławomir Michalak ; MD ; PhDa ; b ; Mikołaj A. Pawlak ; MD ; PhDc ; Jacek Losy ; MD ; PhDd ; b ; jlosy@ump.edu.pl" class="auth_mail" title="E-mail the corresponding author (full professor) ; Wojciech Kozubski ; MD ; PhDe ; wkozubski@ump.edu.pl" class="auth_mail" title="E-mail the corresponding author (full professor)
- 关键词：Optic neuritis ; Multiple sclerosis ; Neuromyelitis optica ; Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) ; Human Vascular Cell Adhesion Molecule-1 (VCAM-1) ; Biomarkers
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：300
- 期：Complete
- 页码：11-14
- 全文大小：764 K
文摘
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Serum levels of PECAM-1 and VCAM-1 could correlate with the risk of progression to MS after first optic neuritis incident.
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sPECAM-1 and sVCAM-1 levels during first optic neuritis are lower in subjects progressing to MS in a 7-year follow-up.
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In our cohort only 2 out of 5 AQP4-IgG (+) optic neuritis patients developed clinically definite NMO in a 7-year follow-up.
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Although AQP4-IgGs are considered highly NMO-specific, it remains uncertain if they may appear in other autoimmune diseases.