Long-term exposure to black carbon, cognition and single nucleotide polymorphisms in microRNA processing genes in older men
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- 作者：Elena Colicinoa ; ecolicin@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Giulia Giulianoa ; g.giuliano6@campus.unimib.it" class="auth_mail" title="E-mail the corresponding author ; Melinda C. Powera ; b ; melinda.c.power@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Johanna Lepeulea ; jlepeule@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Elissa H. Wilkera ; c ; ewilker@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Pantel Vokonasd ; pantel.vokonas@va.gov" class="auth_mail" title="E-mail the corresponding author ; Kasey J.M. Brennana ; kbrennan@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Serena Fossatia ; e ; sfossati@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Mirjam Hoxhaf ; g ; mirjam.hoxha@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Avron Spiro IIId ; aspiro3@bu.edu" class="auth_mail" title="E-mail the corresponding author ; Marc G. Weisskopfa ; b ; mweissko@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Joel Schwartza ; b ; joel@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Andrea A. Baccarellia ; b ; abaccare@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BC ; black carbon ; CERAD ; Consortium to Establish a Registry for Alzheimer Disease ; CI ; confidence interval ; WAIS-R ; Wechsler Adult Intelligence Scales for Adults ; Revised ; FDR ; False Discovery Rate ; miRNA ; microRNA ; mRNA ; messenger RNA ; MET-hr ; metabolic equivalent hours ; MMSE ; Mini-Mental State Examination ; NAS ; Normative Aging Study ; nt ; nucleotide ; OR ; odds ratio ; pri-miRNA ; primary-miRNA ; RISC ; RNA-induces silencing complex ; RNA ; Ribonucleic Acid ; SD ; standard deviation ; SNP ; single nucleoti
- 刊名：Environment International
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：86-93
- 全文大小：362 K
文摘
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Black carbon (BC), marker of air pollution, was adversely associated with cognition.
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SNPs in miRNA processing-genes were adversely associated with cognition.
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SNPs in miRNA processing-genes affected susceptibility to BC–cognition association.
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Susceptibility possibly due to influences on miRNA expression