Granulocyte Colony-Stimulating Factor-Mobilized Allografts Contain Activated Immune Cell Subsets Associated with Risk of Acute and Chronic Graft-versus-Host Disease
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- 作者：Sumithira Vasu1 ; Susan Geyer2 ; Anissa Bingman1 ; Jeffery J. Auletta3 ; Samantha Jaglowski1 ; Pat Elder1 ; Lynn O. Donnell1 ; Hillary Bradbury1 ; Rhonda Kitzler4 ; Leslie Andritsos1 ; William Blum1 ; Rebecca Klisovic1 ; Sam Penza1 ; Yvonne Efebera1 ; Craig Hofmeister1 ; Don M. Benson1 ; Natarajan Muthusamy1 ; 2 ; Gerard Lozanski4 ; &dagger ; ; Steven M. Devine1 ; &dagger ; ; vijigopi24@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allograft content of NK cells ; HLA-DR+ CD3+ cells ; Acute GVHD ; Chronic GVHD ; Leukemic relapse
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：4
- 页码：658-668
- 全文大小：2003 K
文摘
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Activated T cell content in allografts is associated with higher incidences of aGVHD and cGVHD.
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Allograft activated NK cell content is associated with a lower incidence of aGVHD.
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In AML/MDS patients, early activated T and NKT cell content is associated with lower relapse.
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Presence of HLA-Bw4-80Ile+ genotype is associated with lower relapse-free survival.
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Unrelated donors were associated with a higher incidence of aGVHD and lower relapse.