Effect of preoperative factors on visual acuity, corneal flattening, and corneal haze after accelerated corneal crosslinking

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• 作者：Mustafa Koc ; MDAuthor Vitae ; Mehmet Murat Uzel ; MD ; Kemal Tekin ; MD ; ^{kemal_htepe@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Pinar Kosekahya ; MD ; Kemal Ozulken ; MD ; Pelin Yilmazbas ; MD
• 刊名：Journal of Cataract & Refractive Surgery
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：42
• 期：10
• 页码：1483-1489
• 全文大小：203 K

文摘

To evaluate the preoperative characteristics that might influence corneal flattening, visual acuity, and corneal haze after accelerated (9 mW/cm²) corneal collagen crosslinking (CXL).

Setting

Ulucanlar Eye Hospital, Ankara, Turkey.

Design

Retrospective case series.

Methods

Accelerated corneal CXL was performed in eyes with progressive keratoconus. Preoperative characteristics included age, sex, uncorrected distance visual acuity and corrected distance visual acuity (CDVA), maximum keratometry (K), corneal thickness, corneal hysteresis, the corneal resistance factor, cone location, and densitometry values. Regression analysis was performed to determine the predictive factors for accelerated corneal CXL outcomes.

Results

The study included 162 eyes of 146 patients with a mean age of 19.3 years ± 4.4 (SD). There was 0.20 logMAR improvement in CDVA (P = .011), 1.85 diopter flattening in maximum K (P < .001), and 5.84 grayscale unit increase in densitometry (P < .001) at 1 year. Multivariate analysis found that preoperative CDVA was a predictive factor for CDVA improvement (ß coefficient, 0.233; 95% confidence interval [CI], −0.054 to 0.477; P = .003). Preoperative maximum K was a predictive factor for corneal flattening (ß coefficient, 0.506; 95% CI, 0.185 to 0.681; P < .001). Univariate analysis found that preoperative densitometry was a predictive factor for increasing corneal densitometry (ß coefficient, 0.466; 95% CI, −0.122 to 0.683; P = .001) and corneal scar formation (ß coefficient, 0.256; 95% CI, 0.012 to 0.421; P = .041).

Conclusions

Patients with a worse preoperative CDVA and higher maximum K were most likely to have improvement after accelerated CXL. Patients with high preoperative densitometry were most likely to have scar formation after the procedure.

Financial Disclosure

None of the authors has a financial or proprietary interest in any material or method mentioned.