Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes: the predictive value of anti-Müllerian hormone

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• 作者：Fariba Ramezanali^a ; Mahnaz Ashrafi^a ; ^b ; ^{ashrafim@royaninstitute.org" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Mandana Hemat^a ; Arezoo Arabipoor^a ; Samaneh Jalali^a ; Ashraf Moini^a ; ^c ; ^d
• 关键词：anti-Mü ; llerian hormone ; assisted reproductive technology outcome ; luteinizing hormone/follicle-stimulating hormone ratio ; phenotypes ; polycystic ovary syndrome
• 刊名：Reproductive BioMedicine Online
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：32
• 期：5
• 页码：503-512
• 全文大小：494 K

文摘

This cross-sectional study aimed to evaluate IVF/intracytoplasmic sperm injection (ICSI) outcomes in different polycystic ovary syndrome (PCOS) phenotypes (A, B, C and D) compared with a control group and the predictive values of serum anti-Müllerian hormone (AMH) in PCOS phenotypes for main outcomes. This study evaluated 386 PCOS women and 350 patients with male factor infertility. Women with phenotypes A and C had significantly higher concentrations of AMH than those with phenotype B (P < 0.001). Clinical pregnancy rate (CPR) in the phenotype D group (53.3%) was higher than other groups (32.5%, 26.4% and 36.8%, respectively, in phenotypes A, B and C), but not to a significant level. Multivariable regression analysis, after adjusting for women's age and body mass index, revealed that PCOS phenotypes A and B were associated with a decreased CPR compared with the control group (odds ratio [OR]: 0.46, confidence interval [CI]: 0.26–0.8, P = 0.007 and OR: 0.34, CI: 0.18–0.62, P = 0.001, respectively). It seems a combination of hyperandrogenism and chronic anovulation is associated with a negative impact on the CPR in these patients. These results demonstrated that AMH concentration is related to PCO morphology but not predictive for CPR and live birth rate.