New clerodane diterpenoids from the roots of Polyalthia laui

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• 作者：Zhang-Xin Yu¹ ; Yan-Hui Fu¹ ; Guang-Ying Chen ; Xiao-Ping Song ; ^{sxp628@126.com" class="auth_mail" title="E-mail the corresponding author} ; Chang-Ri Han ; ^{hchr116@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Bao Li ; Xin-Ming Song ; Ai-Zhen Wu ; Shi-Chen Chen
• 关键词：Polyalthia laui ; Clerodane diterpenoids ; Polylauiester A ; Polylauiamides B&ndash ; D ; Cytotoxicity
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：111
• 期：Complete
• 页码：36-41
• 全文大小：534 K

文摘

Five new clerodane diterpenoids, polylauiester A (class="boldFont">1), (4 → 2)-abeo-2,13-diformyl-cleroda-2,12E-dien-14-oic acid (class="boldFont">2) and polylauiamides B–D (class="boldFont">3–class="boldFont">5), together with 11 known clerodane diterpenoids (class="boldFont">6–class="boldFont">16), were isolated from the roots of Polyalthia laui. Among them, polylauiester A (class="boldFont">1) represents the first example of a novel norclerodane diterpenoid only containing 17 carbon atoms on the carbon skeleton, and polylauiamide B (class="boldFont">3) is an unusual diterpenoid with a p-substituted benzene ring as a substituent. Their structures were elucidated by extensive spectroscopic methods, and the relative configuration of polylauiamide B (class="boldFont">3) was further confirmed by the single crystal X-ray diffraction method. Biological evaluation of new compounds against human Hela, MCF-7 and A549 human cancer cell lines showed that all compounds displayed weak cytotoxicities against various human cancer cell lines in the range of IC₅₀ at 25.01–39.31 μM.