PRAME is critical for breast cancer growth and metastasis
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- 作者：Zhengwang Suna ; 1 ; Zhipeng Wua ; 1 ; Fenglin Zhangb ; 1 ; Qunfeng Guoa ; 1 ; Lin lia ; Kun lic ; Hui Chenc ; Juan Zhaoc ; Dianwen Songd ; ⁎ ; 2 ; Dianwen_Song@163.com" class="auth_mail" title="E-mail the corresponding author ; Quan Huanga ; ⁎ ; Quan_Huang1234@163.com" class="auth_mail" title="E-mail the corresponding author ; Lei Lic ; ⁎ ; ; Jianru Xiaoa ; jianru_xiao12345@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：EMT ; epithelial-mesenchymal transition ; TGF-β ; transforming growth factor-β ; EGF ; epidermal growth factor ; PRAME ; melanoma antigen preferentially expressed in tumors ; E-cadherin ; epithelial cadherin
- 刊名：Gene
- 出版年：2016
- 出版时间：5 December 2016
- 年：2016
- 卷：594
- 期：1
- 页码：160-164
- 全文大小：1056 K
文摘
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Knockdown of PRAME promotes breast cancer cell proliferation and inhibits apoptosis.
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Inhibition of PRAME promotes the invasion of breast cancer cells.
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Suppression of PRAME increases tumor initiation.