Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats
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- 作者：Dan Wana ; b ; c ; Yehan Zhoua ; b ; c ; Ke Wanga ; c ; Yongying Houa ; c ; Ruihang Houa ; c ; Xiufeng Yea ; b ; c ; yxf1960@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Resveratrol ; Stroke ; SIRT1 ; AMPK ; ATP ; PDEs
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：255-262
- 全文大小：1701 K
文摘
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Resveratrol alleviates injury following cerebral ischemia/reperfusion.
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Resveratrol provides neuroprotection through inhibition of phosphodiesterase 4A, and eventually decreasing ATP consumption.
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Phosphodiesterase 4A may be the direct target of resveratrol for treatment of stroke.