Evaluation of the change in sphingolipids in the human multiple myeloma cell line U266 and gastric cancer cell line MGC-803 treated with arsenic trioxide
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- 作者：Jianhua Zoua ; Xiaoqiong Maa ; maxq126126@126.com" class="auth_mail" title="E-mail the corresponding author ; Guangji Zhangb ; Li Shenb ; Liting Zhouc ; Yu Yua ; Fanfan Zhua ; Zhe Chena ;
- 关键词：DP ; declustering potential ; EP ; entrance potential ; CE ; collision energy ; CXP ; collision cell exit potential ; iAsIII ; AsIII ions ; QTrap ; quadrupole linear-ion trap ; SRM ; selected reaction monitoring ; Cer ; ceramide ; HexCer ; hexosylceramide ; Hex2Cer ; dihexosylceramide ; SM ; sphingomyelin ; Sph ; sphingosine ; dhSph ; sphinganine ; S1P ; sphingosine 1-phosphate ; dhS1P ; sphinganine 1-phosphate
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：1004
- 期：Complete
- 页码：98-107
- 全文大小：1502 K
文摘
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An HPLC-ESI–MS/MS method was applied to investigate the changes in sphingolipids.
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Arsenic trioxide (As2O3) was used to treat human U266 and MGC-803 cells.
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The distributions of sphingolipids are different in the human U266 and MGC-803 cells.
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The levels of Hex2Cer in human U266 cells decreased when treated with As2O3.
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The levels of S1P and dhS1P in human MGC-803 cells decreased when treated with As2O3.