Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells
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- 作者：Yingqiu Zhanga ; b ; 1 ; Jinrui Zhanga ; b ; 1 ; Congcong Liub ; c ; Sha Dub ; Lu Fengd ; Xuelin Luanb ; Yayun Zhangb ; Yulin Shib ; Taishu Wangb ; Yue Wub ; Wei Chengb ; Songshu Mengb ; Man Lia ; liman126126@163.com" class="auth_mail" title="E-mail the corresponding author ; Han Liua ; b ; c ; liuhan@dlmedu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neratinib ; ErbB2 ; HER2 ; Breast cancer ; Ubiquitylation ; Endocytosis
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 November 2016
- 年：2016
- 卷：382
- 期：2
- 页码：176-185
- 全文大小：3248 K
文摘
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Tyrosine kinase inhibitors lapatinib and neratinib show opposite effects on ErbB2 levels.
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Both lapatinib and neratinib treatments elevate ErbB2 mRNA.
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Neratinib induces more potent endocytic degradation via endolysosome system than lapatinib.
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Neratinib triggers ErbB2 ubiquitylation through HSP90 dissociation.