Activating AMP-activated protein kinase by an α1 selective activator compound 13 attenuates dexamethasone-induced osteoblast cell death
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- 作者：Shiguang Guoa ; 1 ; Li Maob ; 1 ; Feng Jic ; huaiaifengjidr@163.com" class="auth_mail" title="E-mail the corresponding author ; Shouguo Wangc ; Yue Xiec ; Haodong Feic ; Xiao-dong Wangd ; xiaodongwangsz@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteoblasts ; Glucocorticoid ; AMP-activated protein kinase (AMPK) ; Compound 13 ; NADPH ; Oxidative stresses
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 March 2016
- 年：2016
- 卷：471
- 期：4
- 页码：545-552
- 全文大小：1100 K
文摘
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Compound 13 (C13) attenuates dexamethasone (Dex)-induced osteoblast cell death.
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C13-induced cytoprotective effect against Dex in osteoblasts requires AMPK activation.
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Forced AMPK activation protects osteoblasts from Dex, nullifying C13's activities.
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C13 increases NADPH activity and inhibits Dex-induced oxidative stress in osteoblasts.