Vaccination with virus-like particles containing H5 antigens from three H5N1 clades protects chickens from H5N1 and H5N8 influenza viruses
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- 作者：Darrell R. Kapczynskia ; Terrence M. Tumpeyb ; Rachmat Hidajatc ; Aniko Zsaka ; Klaudia Chrzasteka ; Irina Tretyakovac ; Peter Pushkoc ; ppushko@medigen-usa.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Avian influenza ; Virus-like particle ; VLP vaccine ; Trivalent
- 刊名：Vaccine
- 出版年：2016
- 出版时间：18 March 2016
- 年：2016
- 卷：34
- 期：13
- 页码：1575-1581
- 全文大小：1258 K
文摘
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Baculovirus vector was prepared for expression of VLPs containing H5 proteins derived from three clades of H5N1 virus.
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Triple-clade H555 VLPs were prepared in Sf9 cells in a single manufacturing cycle.
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VLPs showed hemagglutination activity and morphologically resembled influenza virions.
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Vaccination with H555 VLPs protected chickens from H5N8 and two H5N1 influenza isolates.