Paclitaxel loaded magnetic nanocomposites with folate modified chitosan/carboxymethyl surface; a vehicle for imaging and targeted drug delivery

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• 作者：Shazia Bano^a ; ^b ; ^c ; ^{shaziaphy@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Muhammad Afzal^a ; Mustansar Mahmood Waraich^d ; Khalid Alamgir^e ; Samina Nazir^b ; ^{seegasami01@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Biopolymers ; Folate conjugation ; Magnetic drug release ; Magnetic resonance imaging ; Drug delivery system
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：20 November 2016
• 年：2016
• 卷：513
• 期：1-2
• 页码：554-563
• 全文大小：2007 K

文摘

In this study, Paclitaxel (PTX) containing, bovine serum albumin (BSA) nanoparticles were fabricated via a simple approach. Folic acid (FA) was conjugated to chitosan (CS)/carboxymethyl cellulose (CMC) through an esterification reaction to produce BSA–CS–FA or BSA-CMC-FA conjugates. NiFe₂O₄ noncore (NFs) and PTX were loaded through a heat treatment and by a diffusion process. NFs-BSA–CS and NFs-BSA–CMC–FA with size of about 80 nm, showed superior transversal R₂ relaxation rate of 349 (mM)⁻¹ s⁻¹ along with folate receptor-targeted and magnetically directed functions. NFs-BSA–CS–FA or NFs-BSA–CS–FA were found stable and biocompatible. Application of an external magnetic field effectively enhanced the PTX release from PTX-NFs-BSA–CS–FA or PTX-NFs-BSA–CS–FA and hence tumor inhibition rate. This study validate that NFs-BSA–CS–FA or NFs-BSA–CMC–FA and PTX-NFs-BSA–CS–FA or PTX-NFs-BSA–CS–FA are suitable systems for tumor diagnosis and therapy.