Reusable palladium nanoparticles in one-pot domino Sonogashira-cyclization: regio- and stereo-selective syntheses of (Z)-3-methyleneisoindoline-1-ones and furo[3,2-h]quinolines in water

详细信息    查看全文

• 作者：Rammyani Pal^a ; ^&dagger ; ; Nivedita Chatterjee^a ; ^&dagger ; ; Manas Roy^b ; ^&dagger ; ; El Said A. Nouh^c ; Sabyasachi Sarkar^b ; Parasuraman Jaisankar^a ; Swarbhanu Sarkar^a ; ^{swarbhanu_2005@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author} ; Asish Kumar Sen^a ; ^{aksen@iicb.res.in" class="auth_mail" title="E-mail the corresponding author} ; ^{asishksen@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Palladium nanoparticle ; Ligand free ; Copper free ; Reaction in water ; Sonogashira-cyclization
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：6 January 2016
• 年：2016
• 卷：57
• 期：1
• 页码：43-47
• 全文大小：2204 K

文摘

Nanodomain Pd(0) mediated regio- and stereo-selective synthesis of (Z)-3-methyleneisoindoline-1-ones and furo[3,2-h]quinolines in water was achieved in high yield. The novel one-pot domino-Sonogashira-cyclization protocol is environment friendly as it eliminates the use of ligands, copper, organic solvents or ionic liquids and homogeneous catalysts. More importantly, the nanocatalyst can be recovered in high yield and recycled for five consecutive reactions without any significant loss of reactivity.