Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys
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- 作者：Dan H. Barouch1 ; 2 ; dbarouch@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Khader Ghneim3 ; William J. Bosche4 ; Yuan Li4 ; Brian Berkemeier4 ; Michael Hull4 ; Sanghamitra Bhattacharyya3 ; Mark Cameron3 ; Jinyan Liu1 ; Kaitlin Smith1 ; Erica Borducchi1 ; Crystal Cabral1 ; Lauren Peter1 ; Amanda Brinkman1 ; Mayuri Shetty1 ; Hualin Li1 ; Courtney Gittens5 ; Chantelle Baker5 ; Wendeline Wagner5 ; Mark G. Lewis5 ; Arnaud Colantonio6 ; Hyung-Joo Kang7 ; Wenjun Li7 ; Jeffrey D. Lifson4 ; Michael Piatak Jr.4 ; 8 ; Rafick-Pierre Sekaly3
- 刊名：Cell
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：165
- 期：3
- 页码：656-667
- 全文大小：4509 K
文摘
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Following mucosal SIV infection of rhesus monkeys, the virus disseminates rapidly
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The initial host response to the virus is mediated by components of the inflammasome
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Early proinflammatory signature lacks expression of antiviral restriction factors
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Host responses in the first few days after infection may facilitate SIV replication