Ambulation speed and corresponding mechanics are associated with changes in serum cartilage oligomeric matrix protein
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Ambulatory measures of joint mechanics are associated with serum COMP increase.

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Ambulatory mechanics explain some (61%) of the variance in serum COMP change.

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Ambulation at greater speeds results in a greater serum COMP concentration increase.

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Serum COMP returns to normal levels within 30 min after ambulating 4000 steps.

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