Immunosuppressive therapy alleviates murine cytomegalovirus recurrence by reducing TNF-α post cell transplantation with lethal GVHD
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- 作者：Jiang Denga ; b ; ammsdjxm@163.com" class="auth_mail" title="E-mail the corresponding author ; Jun Xiaoa ; b ; ammsxj@126.com" class="auth_mail" title="E-mail the corresponding author ; Liping Lva ; b ; lvlp2007@sina.com" class="auth_mail" title="E-mail the corresponding author ; Ping Maa ; b ; maping1111@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Xin Songa ; b ; xinxinsophine01@126.com" class="auth_mail" title="E-mail the corresponding author ; Bo Gaoa ; b ; gaobolove@sina.com" class="auth_mail" title="E-mail the corresponding author ; Feng Gonga ; b ; gongfeng@nic.bmi.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Yanyu Zhanga ; b ; swgczhyy@126.com" class="auth_mail" title="E-mail the corresponding author ; Jinbo Xua ; b ; xujb@bmi.ac.cn" class="auth_mail" title="E-mail the corresponding author ; ammsxujb@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytomegalovirus ; Immunosuppressive therapy ; Allogeneic hematopoietic cell transplantation ; Graft-versus-host disease ; TNF-α
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：130-139
- 全文大小：2873 K
文摘
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We established two model of MCMV reactivation with mild and severe GVHD.
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Immunosuppressive therapy alleviated viral load in a mouse model with severe GVHD.
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The protection correlates with reduced GVHD-related injury and TNF-α mechanically.
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TNF-α levels correlated with MCMV recurrence in severe GVHD.