Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
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- 作者：Marco Onorati1 ; 14 ; Zhen Li1 ; 14 ; Fuchen Liu1 ; 14 ; André ; M.M. Sousa1 ; 14 ; Naoki Nakagawa2 ; Mingfeng Li1 ; Maria Teresa Dell&rsquo ; Anno3 ; Forrest O. Gulden1 ; Sirisha Pochareddy1 ; Andrew T.N. Tebbenkamp1 ; Wenqi Han1 ; Mihovil Pletikos1 ; Tianliuyun Gao1 ; Ying Zhu1 ; Candace Bichsel1 ; Luis Varela4 ; Klara Szigeti-Buck4 ; Steven Lisgo5 ; Yalan Zhang6 ; Anze Testen2 ; Xiao-Bing Gao4 ; Jernej Mlakar7 ; Mara Popovic7 ; Marie Flamand8 ; Stephen M. Strittmatter3 ; Leonard K. Kaczmarek6 ; 9 ; E.S. Anton2 ; Tamas L. Horvath1 ; 4 ; 10 ; 11 ; tamas.horvath@yale.edu" class="auth_mail" title="E-mail the corresponding author ; Brett D. Lindenbach12 ; brett.lindenbach@yale.edu" class="auth_mail" title="E-mail the corresponding author ; Nenad Sestan1 ; 3 ; 4 ; 13 ; 15 ; nenad.sestan@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2576-2592
- 全文大小：8183 K
文摘
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Derivation of human neocortical and spinal cord neuroepithelial stem (NES) cells
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Zika virus (ZIKV) infects NES cells and radial glia, impairing mitosis and survival
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ZIKV induces mitochondrial sequestration of centrosomal phospho-TBK1
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Nucleoside analogs inhibit ZIKV replication, protecting NES cells from cell death