Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy
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- 作者：Sied Kebira ; 1 ; Sied.Kebir@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Zacharias Orfanosb ; 1 ; orfanos@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Julia Schuldb ; 1 ; julis@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Markus Linhartc ; Markus.Linhart@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Christian Lamberzb ; christian.lamberz@dzne.de" class="auth_mail" title="E-mail the corresponding author ; Peter F.M. van der Venb ; pvdven@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Jan Schrickelc ; Jan.Schrickel@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Gregor Kirfelb ; g.kirfel@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Dieter O. Fü ; rstb ; 2 ; dfuerst@uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Rainer Meyera ; 2 ; rainer.meyer@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Xin actin-binding repeat-containing proteins ; Xirp1 ; XIRP2 ; Cross-striated muscle cells ; Connexin43 ; Filamin C
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：348
- 期：1
- 页码：95-105
- 全文大小：787 K
文摘
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TAC induced remodeling in areas adjacent to intercalated disks.
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Hypertrophic hearts show sarcomeric lesions like post-exercise skeletal muscles.
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Filamin C and XIRP2 are markers of sarcomeric remodeling in the heart.
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Xirp1-inactivated hearts only display a very mild phenotype.