Cisplatin-crosslinked glutathione-sensitive micelles loaded with doxorubicin for combination and targeted therapy of tumors
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- 作者：Xueqiong Zhanga ; Lianghong Lia ; Chunfu Lia ; Hua Zhenga ; Haoyuan Songa ; Fuliang Xionga ; Tong Qiu ; Ph.D.b ; tongttqq@whut.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jin Yang ; Ph.D.c ; jade_0422@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carboxymethyl chitosan ; Micelles ; Cisplatin ; Doxorubicin ; Combination therapy ; Drug delivery
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：2 January 2017
- 年：2017
- 卷：155
- 期：Complete
- 页码：407-415
- 全文大小：2174 K
文摘
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The micelles were designed for synergistic cisplatin-doxorubicin combination chemotherapy.
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The micelles were tumor-targeting and glutathione-sensitive.
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The crosslinked micelles were formed via chelate interactions between the ionic polymeric carrier and the cisplatin.