Conditionally replicating HIV and SIV variants
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- 作者：Atze T. Das ; a.t.das@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author ; Ben Berkhout b.berkhout@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIV ; SIV ; AIDS vaccine ; Conditional replication ; Live-attenuated virus ; Tet-On system
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 May 2016
- 年：2016
- 卷：216
- 期：Complete
- 页码：66-75
- 全文大小：1839 K
文摘
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We developed conditionally replicating HIV-1 and SIV variants.
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HIV-rtTA and SIV-rtTA replicate exclusively in the presence of doxycycline.
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These designer viruses were optimized through spontaneous virus evolution.
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The optimized viruses replicate in cell and tissue cultures and in animal models.
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These viruses are valuable tools in HIV and SIV biology studies and vaccine research.