Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation
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- 作者：Gillian A. Matthews1 ; 2 ; 3 ; Edward H. Nieh1 ; 3 ; Caitlin M. Vander Weele1 ; 3 ; Sarah A. Halbert1 ; Roma V. Pradhan1 ; Ariella S. Yosafat1 ; Gordon F. Glober1 ; Ehsan M. Izadmehr1 ; Rain E. Thomas1 ; Gabrielle D. Lacy1 ; Craig P. Wildes1 ; Mark A. Ungless2 ; 4 ; mark.ungless@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Kay M. Tye1 ; 4 ; kaytye@mit.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：11 February 2016
- 年：2016
- 卷：164
- 期：4
- 页码：617-631
- 全文大小：5778 K
文摘
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Dorsal raphe nucleus (DRN) dopamine neurons are sensitive to acute social isolation
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DRN dopamine neurons release dopamine and glutamate in downstream structures
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Optical activation induces, whereas inhibition suppresses, a “loneliness-like” state
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Social rank predicts the behavioral effect induced by optical manipulations