Progesterone improves long-term functional and histological outcomes after permanent stroke in older rats
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- 作者：Bushra Wali bwali@emory.edu" class="auth_mail" title="E-mail the corresponding author ; Tauheed Ishrat TISHRAT@gru.edu" class="auth_mail" title="E-mail the corresponding author ; Donald G. Stein dstei04@emory.edu" class="auth_mail" title="E-mail the corresponding author ; Iqbal Sayeed ; isayeed@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; ANOVA ; analysis of variance ; CCA ; common carotid artery ; GFAP ; glial fibrillary acidic protein ; HBC ; 2-hydroxypropyl-b-cyclodextrin ; LSD ; least significant difference ; MCA ; middle cerebral artery ; MWM ; Morris Water Maze ; NBQX ; N-type calcium channel antagonist ; NMDA ; N-Methyl-d-aspartate ; PBS ; phosphate-buffered saline ; pMCAO ; permanent middle cerebral artery occlusion ; PROG ; progesterone ; RT ; room temperature ; SNX-111 ; Zicontide ; STAIR
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：46-56
- 全文大小：2454 K
文摘
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Progesterone was evaluated for neuroprotection in older rats with permanent stroke.
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Progesterone treatment improved long-term motor, sensory and learning function.
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Progesterone-treated animals showed attenuation of infarct volume.
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Progesterone treatment decreased glial fibrillary acidic protein expression.