Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia
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- 作者：Ngai Cheung1 ; Tsz Kan Fung1 ; Bernd B. Zeisig1 ; Katie Holmes1 ; Jayant K. Rane1 ; Kerri A. Mowen2 ; Michael G. Finn3 ; Boris Lenhard4 ; Li Chong Chan5 ; Chi Wai Eric So1 ; eric.so@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：histone methyltransferase ; histone demethylase ; leukemia epigenetics ; KMT ; PMT ; KDM ; PRMT1 ; KDM4C ; MLL fusions ; MOZ-TIF2 ; acute myeloid leukemia ; AML
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：11 January 2016
- 年：2016
- 卷：29
- 期：1
- 页码：32-48
- 全文大小：5378 K
文摘
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PRMT1 recruitment is necessary but not sufficient for transformation by AML fusions
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MLL fusions and MOZ-TIF2 recruit KDM4C to remove H3K9me3 repressive marks
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KDM4C and PRMT1 regulate aberrant epigenetic and transcriptional networks in AML
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Molecular or pharmacology inhibition of KDM4C or PRMT1 suppresses AML