PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation
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- 作者：Brianna J. Klein1 ; 6 ; Xiaoyan Wang2 ; 4 ; 6 ; Gaofeng Cui3 ; 6 ; Chao Yuan2 ; Maria Victoria Botuyan3 ; Kevin Lin2 ; Yue Lu2 ; Xiaolu Wang2 ; Yue Zhao5 ; Christiane J. Bruns4 ; 5 ; Georges Mer3 ; mer.georges@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Xiaobing Shi2 ; xbshi@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Tatiana G. Kutateladze1 ; 7 ; tatiana.kutateladze@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PHF20 ; MOF ; p53 ; histone methylation ; histone acetylation ; PHD finger ; Tudor ; chromatin
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：1158-1170
- 全文大小：4673 K
文摘
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PHF20 is essential in cancer cell growth and survival
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The PHD finger of PHF20 exhibits high selectivity for H3K4me2
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H3K4me2 binding is necessary for MOF-dependent H4K16 acetylation and gene regulation
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PHF20 functions link MOF HAT, p53, and H3K4me2