Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction
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- 作者：Alexandra Mikhailovaa ; alexandra.mikhailova@uta.fi" class="auth_mail" title="E-mail the corresponding author ; Tanja Ilmarinena ; tanja.ilmarinen@uta.fi" class="auth_mail" title="E-mail the corresponding author ; Anjula Ratnayakeb ; aratnayake@linkocare.com" class="auth_mail" title="E-mail the corresponding author ; Goran Petrovskic ; petrovski.goran@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author ; Hannu Uusitalod ; hannu.uusitalo@uta.fi" class="auth_mail" title="E-mail the corresponding author ; Heli Skottmana ; 1 ; heli.skottman@uta.fi" class="auth_mail" title="E-mail the corresponding author ; Mehrdad Rafatb ; e ; 1 ; mehrdad.rafat@liu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Corneal epithelium ; Limbal epithelial stem cells ; Human pluripotent stem cells ; Serum-free culture conditions ; Tissue engineering ; Regenerative medicine
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：26-34
- 全文大小：2302 K
文摘
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Human PSCs can generate a virtually limitless supply of LESC-like cells.
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Cultured on bioengineered matrices, hPSC-LESCs self-renewed and proliferated.
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The bioengineered matrix studied here could partially replace the damaged stroma.
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The study was carried out in serum-free and feeder-free conditions.
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We propose this novel tissue engineering approach for corneal reconstruction.