A Therapeutic Antibody for Cancer, Derived from Single Human B Cells
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- 作者：Ryan T. Bushey1 ; 10 ; M. Anthony Moody2 ; 3 ; 4 ; 10 ; Nathan L. Nicely2 ; Barton F. Haynes2 ; 4 ; 5 ; S. Munir Alam2 ; Stephen T. Keir6 ; Rex C. Bentley7 ; Kingshuk Roy Choudhury1 ; 8 ; Elizabeth B. Gottlin1 ; Michael J. Campa1 ; Hua-Xin Liao2 ; 5 ; hliao@duke.edu" class="auth_mail" title="E-mail the corresponding author ; Edward F. Patz Jr.1 ; 9 ; patz0002@mc.duke.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：15
- 期：7
- 页码：1505-1513
- 全文大小：2195 K
文摘
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Recombinant CFH mAbs were derived from B cells of patients with CFH autoantibodies
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Recombinant CFH mAbs promote tumor cell lysis and cause release of anaphylatoxins
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Recombinant murine CFH mAbs inhibit tumor growth in mice