Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
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- 作者：Eoin McDonnell1 ; 2 ; Scott B. Crown1 ; Douglas B. Fox3 ; Betü ; l Kitir4 ; Olga R. Ilkayeva1 ; Christian A. Olsen4 ; Paul A. Grimsrud1 ; Matthew D. Hirschey1 ; 2 ; 3 ; 5 ; matthew.hirschey@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：histone ; acetylation ; epigenetics ; metabolism ; fatty acid ; lipids ; gene expression ; proteomics ; metabolomics
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：17
- 期：6
- 页码：1463-1472
- 全文大小：2297 K
文摘
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Fatty acid oxidation increases global histone acetylation
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Lipids can provide up to 90% of acetyl-carbon for histone acetylation
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Octanoate reprograms metabolism and becomes the major source of acetyl-CoA
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Lipid-derived acetyl-CoA promotes lipid-specific gene expression