Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion
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- 作者：Srinika Ranasinghe1 ; 13 ; 14 ; sranasinghe@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Pedro A. Lamothe1 ; 2 ; 3 ; 13 ; Damien Z. Soghoian1 ; Samuel W. Kazer1 ; 4 ; 5 ; Michael B. Cole6 ; Alex K. Shalek1 ; 4 ; 5 ; Nir Yosef1 ; 6 ; R. Brad Jones1 ; 7 ; Faith Donaghey1 ; Chioma Nwonu1 ; Priya Jani1 ; Gina M. Clayton3 ; 8 ; Frances Crawford3 ; 8 ; Janice White8 ; Alana Montoya8 ; Karen Power1 ; Todd M. Allen1 ; Hendrik Streeck9 ; 10 ; Daniel E. Kaufmann1 ; 11 ; Louis J. Picker12 ; John W. Kappler3 ; 8 ; Bruce D. Walker1 ; 2 ; 3 ; 4 ; 5 ; bwalker@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIV ; TCR ; CD8+ T cells ; vaccines ; HLA ; MHC class II
- 刊名：Immunity
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：45
- 期：4
- 页码：917-930
- 全文大小：2820 K
文摘
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CD8+ T cells restricted by HLA-DRB1 exist in a small number of HIV-infected persons
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These CD8+ T cells exhibit potent antiviral functions against HIV-infected cells
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TCRβ usage patterns indicate clonal expansion of class II-restricted CD8+ T cells
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CD8+ T cells that violate immunologic paradigms may contribute to viral control