Fucoidan improves bioactivity and vasculogenic potential of mesenchymal stem cells in murine hind limb ischemia associated with chronic kidney disease
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- 作者：Jun Hee Leea ; 1 ; Jung Min Ryub ; c ; 1 ; Yong-Seok Hand ; e ; Mohammad Farid Ziaf ; Hyog Young Kwonf ; Hyunjin Nohg ; h ; nohneph@schmc.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Ho Jae Hanb ; hjhan@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Sang Hun Leed ; e ; ykckss1114@nate.com" class="auth_mail" title="E-mail the corresponding author ; jhlee0407@sch.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Akt ; Protein kinase B (PKB) ; CDK ; Cyclin-dependent kinase ; CKD ; Chronic kidney disease ; DAPI ; 4&prime ; 6-Diamidino-2-phenylindole ; ERK ; Extracellular signal-regulated kinase ; FAK ; Focal adhesion kinase ; HNA ; Human nuclear antigen ; IDO ; Indoleamine-pyrrole 2 ; 3-dioxygenase ; MSC ; Mesenchymal stem cells ; PCNA ; Proliferating cell nuclear antigen ; PI3K ; Phosphatidylinositol-4 ; 5-bisphosphate 3-kinase
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：169-179
- 全文大小：2216 K
文摘
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Fucoidan enhances the proliferation of MSCs through FAK-Akt axis.
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Fucoidan increases the immunomodulatory activity of MSCs via ERK-IDO-1 pathway.
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Transplantation of fucoidan-treated MSCs augments the functional recovery in CKD mice with hind limb ischemia.