Promotor sequences of arginase and agmatinase genes were identified firstly in Apostichopus japonicus.
Ajargianse and Ajagmatinase promoter activities were induced by LPS exposure and class="smallcaps">l-arginine treatment.
The region −673/+25 and −648/+32 both contributed importantly to expression of the Ajargianse and Ajagmatinase, respectively.
NF-κB/Rel and STAT5 could significantly inhibited Ajargianse promoter activity, but not Ajagmatinase.