Lack of support for bexarotene as a treatment for Alzheimer's disease
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- 作者：Eugene O'Harea ; e.ohare@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Ross Jeggob ; r.jeggo@neurosolutionsltd.com" class="auth_mail" title="E-mail the corresponding author ; Eun-Mee Kimc ; e.kim@ulster.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Bridgeen Barboura ; bmcmahon09@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Jean-Sebastien Walczakd ; jswalczak@cerebrasol.com" class="auth_mail" title="E-mail the corresponding author ; Philip Palmera ; ppalmer01@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Taylor Lyonsa ; tlyons03@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Deaglan Pagea ; d.page@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Donncha Hannaa ; donncha.hanna@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Jolyon R. Mearae ; jolyon.meara@wales.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; David Spanswickb ; d ; f ; david.spanswick@monash.edu" class="auth_mail" title="E-mail the corresponding author ; Jian-Ping Guog ; Edith G. McGeerg ; Patrick L. McGeerg ; mcgeerpl@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Peter Hobsone ; peter.hobson@wales.nhs.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bexarotene ; Alzheimer's disease ; Beta-amyloid ; Oligomers ; Synaptic transmission ; Behavior
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：124-130
- 全文大小：1309 K
文摘
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Amyloid-尾 is a central endogenous pathogen in Alzheimer's disease (AD).
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Soluble A尾 oligomers are the major cause of synaptotoxicity/neurodegeneration in AD.
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Bexarotene administration has been proposed as a potential treatment for AD.
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Bexarotene administration had no effects on histology or electrophysiology.
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Bexarotene administration had no effects on A尾-induced cognitive decline.