Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer
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- 作者：Jonathan C. Irisha ; b ; 1 ; jirish9@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jamie N. Millsa ; 1 ; millsjn@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Brittany Turner-Iveya ; turnerbp@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Robert C. Wilsona ; wilsorc@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Stephen T. Guesta ; guests@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Alexandria Rutkovskya ; rutkovsk@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Alan Dombkowskib ; domski@wayne.edu" class="auth_mail" title="E-mail the corresponding author ; Christiana S. Kapplera ; kapplerc@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Gary Hardimanc ; hardiman@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Stephen P. Ethiera ; ethier@musc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer ; Oncogenes ; Epigenomics ; Estrogen receptor ; Estrogen-independence
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：10
- 期：6
- 页码：850-865
- 全文大小：3143 K
文摘
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SUM44 is a model cell line for ERα positive breast cancer with the 8p11 amplicon.
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WHSC1L1 is a driving oncogene from the 8p11 amplicon in SUM44 cells.
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SUM44 breast cancer cells have high ERα expression, regulated by WHSC1L1 knockdown.
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ERα is required for growth and survival of SUM44 cells but is estrogen-independent.
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WHSC1L1 knock-down re-sensitizes ERα to estradiol for binding to essential genes.