Brain Dysplasia Associated with Ciliary Dysfunction in Infants with Congenital Heart Disease

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• 作者：Ashok Panigrahy ; MD¹ ; ² ; ^{panigrahya@upmc.edu" class="auth_mail" title="E-mail the corresponding author} ; Vincent Lee ; BS¹ ; Rafael Ceschin ; MS¹ ; ² ; Giulio Zuccoli ; MD¹ ; Nancy Beluk ; BS¹ ; Omar Khalifa ; BS³ ; Jodie K. Votava-Smith ; MD⁴ ; Mark DeBrunner ; MD⁵ ; Ricardo Munoz ; MD⁶ ; Yuliya Domnina ; MD⁶ ; Victor Morell ; MD⁷ ; Peter Wearden ; MD⁷ ; Joan Sanchez De Toledo ; MD⁶ ; William Devine ; BS³ ; Maliha Zahid ; MD³ ; Cecilia W. Lo ; PhD³
• 关键词：extraaxial CSF ; olfactory ; choroid plexus ; hippocampus ; motile cilia
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：178
• 期：Complete
• 页码：141-148.e1
• 全文大小：1183 K

文摘

To test for associations between abnormal respiratory ciliary motion (CM) and brain abnormalities in infants with congenital heart disease (CHD)

Study design

We recruited 35 infants with CHD preoperatively and performed nasal tissue biopsy to assess respiratory CM by videomicroscopy. Cranial ultrasound scan and brain magnetic resonance imaging were obtained pre- and/or postoperatively and systematically reviewed for brain abnormalities. Segmentation was used to quantitate cerebrospinal fluid and regional brain volumes. Perinatal and perioperative clinical variables were collected.

Results

A total of 10 (28.5%) patients with CHD had abnormal CM. Abnormal CM was not associated with brain injury but was correlated with increased extraaxial cerebrospinal fluid volume (P < .001), delayed brain maturation (P < .05), and a spectrum of subtle dysplasia including the hippocampus (P < .0078) and olfactory bulb (P < .034). Abnormal CM was associated with higher composite dysplasia score (P < .001), and both were correlated with elevated preoperative serum lactate (P < .001).

Conclusions

Abnormal respiratory CM in infants with CHD is associated with a spectrum of brain dysplasia. These findings suggest that ciliary defects may play a role in brain dysplasia in patients with CHD and have the potential to prognosticate neurodevelopmental risks.