Development and validation of an at-line fast and non-destructive Raman spectroscopic method for the quantification of multiple components in liquid detergent compositions
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- 作者：D. Brouckaerta ; davinia.brouckaert@ugent.be" class="auth_mail" title="E-mail the corresponding author ; J.-S. Uyttersprotb ; uyttersprot.js@pg.com" class="auth_mail" title="E-mail the corresponding author ; W. Broeckxb ; broeckx.wa@pg.com" class="auth_mail" title="E-mail the corresponding author ; T. De Beera ; thomas.debeer@ugent.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：Process analytical technology ; Raman spectroscopy ; Chemometrics ; Method validation ; Measurement uncertainty
- 刊名：Analytica Chimica Acta
- 出版年：2016
- 出版时间：19 October 2016
- 年：2016
- 卷：941
- 期：Complete
- 页码：26-34
- 全文大小：905 K
文摘
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Raman spectroscopy as PAT tool monitoring a liquid detergent production process.
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SIMCA classification model distinguishing between investigated cleaning liquids.
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Quantitative PLS models for determination of the main ingredients concentration.
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Method validation and uncertainty analysis through the accuracy profile approach.
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Developed method demonstrated suitable for routine use at-line.