Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
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- 作者：Kumar Sanjiv1 ; Anna Hagenkort1 ; José ; Manuel Calderó ; n-Montañ ; o1 ; Tobias Koolmeister1 ; Philip M. Reaper2 ; Oliver Mortusewicz1 ; Sylvain A. Jacques1 ; Raoul V. Kuiper3 ; Niklas Schultz1 ; Martin Scobie1 ; Peter A. Charlton2 ; John R. Pollard2 ; Ulrika Warpman Berglund1 ; Mikael Altun1 ; Thomas Helleday1 ; thomas.helleday@scilifelab.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATR ; CHK1 ; synthetic lethality ; cancer ; DNA damage ; replication stress
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 January 2016
- 年：2016
- 卷：14
- 期：2
- 页码：298-309
- 全文大小：4813 K
文摘
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Synthetic lethality within the same pathway is via the induction of replication catastrophe
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New origin firing and replication stress induced by CHK1 inhibitor reliance on ATR
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ATR and CHK1 inhibitor combination results in cancer-specific cytotoxicity
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ATR and CHK1 inhibitor combination could be used broadly across cancer indications